Активность

Seventy days after repair, tetanic muscle strength, muscle mass, axon inner diameter, and g-ratio were equivalent among all groups. Axon counts were equivalent between the nylon suture and Evicel groups, although in the nylon group axon counts were higher than for the Tisseel group.

In an animal model with a 3-day delay in nerve repair, although dehiscences occurred, when the initial repair held, fibrin glue was not inferior to nylon suture with regard to repair strength and muscle recovery.

Historical concerns regarding spontaneous fibrin glue-based nerve repair dehiscences are well-founded. However, when coaptation is maintained, commercially available fibrin glues support nerve regeneration.

Historical concerns regarding spontaneous fibrin glue-based nerve repair dehiscences are well-founded. However, when coaptation is maintained, commercially available fibrin glues support nerve regeneration.The correction of global kyphosis (GK) for ankylosing spondylitis (AS) patients with pre-existing pseudarthrosis were frequently over 45°. Mismatch between kyphosis correction of GK and pedicle subtraction osteotomy (PSO) may be ascribed to contribution of pseudarthrosis. The aim of the present study was to evaluate surgical outcomes of PSO away from the level of pseudarthrosis and to elucidate the contribution of pre-existing spinal pseudarthrosis in surgical correction of thoracolumbar kyphosis caused by AS. Eighteen AS patients with pre-existing pseudarthrosis were included. PSO outside the level of pseudarthrosis were performed for all the patients. The average follow-up period were 29 months. Radiographs were analyzed for correction and complications. Significant improvement in all sagittal parameters were found postoperatively without obvious correction loss at the final follow-up. Local kyphosis (LK) improved from 23.88° preoperatively to 12.67° postoperatively with a mean correction of 11.47°. Average correction of per PSO segment, GK and sum of disc wedging within fused region (SDW) were 33.53°, 49.27° and 4.00°, respectively. PSO away from the level of pseudarthrosis, but with posterior instrumentation crossing it was a feasible method and was able to maintain sustained surgical outcomes. Regarding GK correction, PSO accounted for 68.1% while pre-existing pseudarthrosis provided 23.3%, which resulted from anterior column opening postoperatively. Thus, extra kyphosis correction attributed to pre-existing pseudarthrosis should be considered for surgical-decision making to prevent overcorrection.

Therapeutic decisions often seem to be the product of interaction between health professionals and patients alone. However, some realities make it essential to consider family members when examining care of patients, especially in the construction of therapeutic choices. Implementation of measures such as therapeutic patient education to make the patient an actor in his own healthcare, and the impact of disease on the patient’s social and professional activities mean there is an important place for family members in a patient’s care pathway. This study aims to examine the role of family members and the family environment in decision-making on treatment for patients with chronic kidney disease. It also analyzes how they contribute to the construction of patients’ choices on dialysis methods through their involvement in a therapeutic patient education program.

This study involved thirty-six semi-structured interviews sixteen with patients and twenty with health professionals. Therapeutic patient education stion of the needs, values, and preferences of family members in mechanisms designed to promote patient participation in therapeutic decisions.Systems biology is an approach that employs modern biological techniques and methods to combine the overall regulation of the body by Chinese herbal formulas with systems analysis at the molecular level. In this study, the underlying immunomodulatory mechanisms of yupingfeng granules (YPFG) were investigated based on the integration of metabolomics and network pharmacology methods. Selected routine peripheral blood indicators, body weight, and organ indices related to immunity were firstly measured in order to evaluate the effects of YPFG in cyclophosphamide-induced immunocompromised rats. Plasma metabolomics analyses were carried out by UPLC-Q-TOF-MS combined with a multivariate data analysis. Our study indicates that the potential regulatory mechanism was related to bile acid and glycerophospholipid metabolism, involving the regulation of 11 metabolites, including 8 bile acids, 1 phosphatidylserine, and 2 phosphatidylethanolamines. see more By means of network pharmacology, the compound-target network between potential active components of YPFG and immune dysregulation was constructed, which releated to estrogen receptor, PPAR, MAPK, PI3K-Akt, JNK signaling pathways, and ubiquitin-mediated protein degradation. The immunomodulatory effect of YPFG may be exerted through regulating lipid metabolism, then bile acid metabolism and inflammation were affected. Biological verification was also performed on cyclophosphamide-induced immunocompromised BALB/c mice. Flavonoid and saponin, two types of compounds in YPFG, were found to be the major active ingredients in the immunomodulatory effects of YPFG, and these components may regulate the abnormal metabolism of bile acids by enhancing the expression of FXR and LXRα. This work elucidated active ingredients, potential biomarkers, and mechanisms of action in the immunoregulatory effects of YPFG from the perspective of systems biology, which provides a scientific basis for its precise clinical medication.We report an outbreak of bovine paralytic rabies in a feed lot in a disease-free area in southern Santa Fe, Argentina. Six of 122 unvaccinated steers died after showing neurological signs (morbimortality = 4.9%) for 24-72 hours, 40-75 days after being transported to the feed lot from a farm located in Formosa. Pathologic examination of the brain in 3 steers revealed gliosis, lymphoplasmacytic meningoencephalitis, and intracytoplasmic inclusion bodies in neurons, along with intralesional detection of the rabies virus antigen by immunohistochemistry in 2 cases. Rabies virus was confirmed by direct immunofluorescence in the brain, and further identified as variant 3a, typical of hematogenous bats, by inoculation in mice followed by indirect immunofluorescence. This represents the first communication of bovine paralytic rabies described in the Pampas plain in Argentina, and evidences that the transport of cattle from endemic to disease-free areas could represent a mechanism of dissemination of this communicable zoonotic disease.